Prather Ranch Pharmaceutical's closed herds are raised using detailed 'Standard Operating Procedures' that focus on animal safety and prevention of disease. For example, all syringes used for vaccinations and injections are immediately disposed of after each use, thus preventing the spread of disease from blood-born pathogens. The herds are also routinely tested for various diseases such as Bovine Leukemia.

Additionally, the herds have been tended to by the same veterinary clinic since its inception. This degree of continuous medical care and supervision, combined with the on-site genealogical records, comprise an extensive database of health history for individual cattle as well as the herd as a whole.

The environments the closed herd cattle are raised in have been methodically chosen to prevent the interaction between cattle and other animals, particularly deer. Equal attention has been paid to the food and water sources that the cattle consume. The cattle graze on pristine ranch land, where the soil and the water supplies are routinely tested for non-indigenous trace elements. The ranch also cultivates the supplemental organically grown feed, thus providing a tightly controlled and heavily monitored food supply chain for its cattle.